Исследования

Repropharma^® специализируется на разработке и производстве продуктов для Репродуктологии. Все продукты компании проходят тщательные клинические исследования в лучших репродуктивных центрах Европы. Так же, выходя на локальные рынки обязательно проводятся клинические исследования в ведущих репродуктивных центрах данной страны. Здесь вы можете ознакомится с европейскими и украинскими клиническими исследованиями наших продуктов и их компонентов:

FertilMan Plus™

Эффективность FertilMan Plus™ была доказана на базе «Медицинского центра лечения бесплодия» (г. Черновцы) под наблюдением президента Украинской ассоциации репродуктивной медицины, д.м.н., профессора Юзько А.М.

Исследования, которые могут вас заинтересовать (номера ссылок в скобках):

L-карнитин: (см. ссылку 1-4)
L-аргинин: (5-7)
Цинк: (8-10)
Селен: (11)
Витамин B12: (12,15)
Витамин A: (13-14)
Витамин C : (16-18)
Витамин Е: (19-21)
Глутатион: (21-24)
Коэнзим Q10: (25-26)
Витамин D: (27)
Витамин B1 (тиамин) (28-29)

(1) Costa M et al. L-Carnitine in idiopathic asthenozoospermia: a multicenter study. Italian Study Group on Carnitine and Male Infertility. Andrologia. 1994 May-Jun;26(3):155-9

(2) Lenzi A, Lombardo F, Gandini L, Dondero F. Metabolism and action of L-Carnitine: its possible role in sperm tail function. Arch Ital Urol Nefrol Androl. 1992 Jun;64(2):187-96.

(3) Menchini-Fabris GF et al. Free L-Carnitine in human semen: its variability in different andrologic pathologies. Fertil Steril. 1984 Aug;42(2):263-7.

(4) Vitali G, Parente R, Melotti C. Carnitine supplementation in human idiopathic.

(5) Scibona M et al. L-Arginine and male infertility. Minerva Urol Nefrol. 1994 Dec;46(4):251-3.

(6) Schachter A et al. Treatment of oligospermia with the amino acid Arginine. Int J Gynaecol Obstet. 1973 Sep;11(5):206-9.

(7) Lewin, A et al. Studies on Arginine in human semen. 3. The influences of several drugs on male infertility. Bull Osaka Med Sch. 1967 Oct;13(2):90-100.

(8) Tikkiwal M et al. Effect of Zinc administration on seminal zinc and fertility of oligospermic males. Indian J Physiol Pharmacol. 1987 Jan-Mar;31(1):30-4

(9) Takihara H, Cosentino MJ, Cockett AT. Zinc sulfate therapy for infertile male with or without varicocelectomy. Urology. 1987 Jun;29(6):638-41

(10) Madding CI, Jacob M, Ramsay VP, Sokol RZ. Serum and semen Zinc levels in normozoospermic and oligozoospermic men. Ann Nutr Metab. 1986;30(4):213-8.

(11) Moslemi, M et al. Selenium – Vitamin E supplementation in infertile men: effects on semen parameters and pregnancy rate. Int J Gen Med 2011;4:99-104

(12) Moriyama H, et al. Studies on the usefulness of a long-term, high-dose treatment of methylcobalamin in patients with oligozoospermia. Hinyokika Kiyo. 1987 Jan;33(1):151-6.

(13) Hermes, R et al. Improvement of male fertility by long-term beta carotene supplementation in white rhinoceros. Institute for zoo and wildlife research, 2003.

(14) Almbro, M. et al. Effects of Vitamin E and beta-carotene on sperm competitiveness. Ecology Letters doi: 10.1111/j.1661-0248.2011.01653.x

(15) Sandler, B et al. The treatment of oligospermia with stilbestrol and vitamin B. Fertil Steril. 1961 Sep-Oct;12:469-73.

(16) C G Fraga, et al. Ascorbic acid protects against endogenous oxidative DNA damage in human sperm. Proc Natl Acad Sci U S A. 1991 December 15; 88(24): 11003–11006.

(17) Colagar AH, Marzony ET. Ascorbic Acid in human seminal plasma: determination and its relationship to sperm quality. J Clin Biochem Nutr. 2009 Sep;45(2):164-9.

(18) Dawson EB, Harris WA, Teter MC, Powell LC. Effect of ascorbic acid supplementation on the sperm quality of smokers. Fertil Steril. 1992 Nov;58(5)1034-9.

(19) Kessopoulou E et al. A double-blind randomized placebo cross-over controlled trial using the antioxidant vitamin E to treat reactive oxygen species associated male infertility. Fertil Steril. 1995 Oct;64(4):825-31.

(20) Geva E et al. The effect of antioxidant treatment on human spermatozoa and fertilization rate in an in vitro fertilization program. Fertil Steril. 1996 Sep;66(3):430-4.

(21) Shamsi, M.B., S. Venkatesh, M. Tanwar, P. Talwar, R.K. Sharma, A. Dhawan, R. Kumar, N.P. Gupta, N. Malhotra, and N. Singh. “DNA Integrity and Semen Quality in Men with Low Seminal Antioxidant Levels.” Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 665.1-2 (2009): 29-36. Print.

(22) Lenzi, A., F. Culasso, L. Gandini, F. Lombardo, and F. Dondero. “Placebo-controlled, Double-blind, Cross-over Trial of Glutathione Therapy in Male Infertility.” Hum. Reprod. 8.10 (1993): 1657-62. Print.

(23) Lenzi, A., F. Lombardo, L. Gandini, F. Culasso, and F. Dondero. “Glutathione Therapy for Male Infertility.” Arch Androl 29.1 (1992): 65-8. Print.

(24) Lenzi A et al. Glutathione therapy for male infertility. Arch Androl. 1992 Jul-Aug;29(1):65-8.

(25) Lewin A, Lavon H. The effect of coenzyme Q10 on sperm motility and function. Mol Aspects Med 1997; 18: S213-19

(26) Lewin A, Lavon H. The effect of coenzyme Q10 on sperm motility and function. Mol Aspects Med 1997; 18: S213-19.

(27) Pilz S et al. Effect of vitamin D supplementation on testosterone levels in men. Horm Metab Res. 2011 Mar;43(3):223-5.

(28) Fleming JC et al. Male infertility and thiamine-dependent erythroid hypoplasia in mice lacking Thiamine transporter Slc19a2. Mol Genet Metab. 2003 Sep-Oct;80(1-2):234-41.

(29) Oishi K, et al. Male infertility due to germ cell apoptosis in mice lacking the Thiamin carrier, Tht1. A new insight into the critical role of Thiamin in spermatogenesis. Dev Biol. 2004 Feb 15;266(2):299-309.

FertilMan™

Исследования, которые могут вас заинтересовать (номера ссылок в скобках):

L-карнитин: (см. ссылку 1-4)
L-аргинин: (5-7)
Цинк: (8-10)
Селен: (11)
Витамин В₁₂: (12-13)
Витамин С: (14-15)
Витамин Е : (16-18)
Глутатион: (19-22)
Коэнзим Q₁₀: (23-24)
Витамин D₃: (25)

(1) Costa M et al. L-Carnitine in idiopathic asthenozoospermia: a multicenter study. Italian Study Group on Carnitine and Male Infertility. Andrologia. 1994 May-Jun;26(3):155-9

(2) Lenzi A, Lombardo F, Gandini L, Dondero F. Metabolism and action of L-Carnitine: its possible role in sperm tail function. Arch Ital Urol Nefrol Androl. 1992 Jun;64(2):187-96.

(3) Menchini-Fabris GF et al. Free L-Carnitine in human semen: its variability in different andrologic pathologies. Fertil Steril. 1984 Aug;42(2):263-7.

(4) Vitali G, Parente R, Melotti C. Carnitine supplementation in human idiopathic

(6) Schachter A et al. Treatment of oligospermia with the amino acid Arginine. Int J Gynaecol Obstet. 1973 Sep;11(5):206-9.

(7) Lewin, A et al. Studies on Arginine in human semen. 3. The influences of several drugs on male infertility. Bull Osaka Med Sch. 1967 Oct;13(2):90-100.

(8) Tikkiwal M et al. Effect of zinc administration on seminal zinc and fertility of oligospermic males. Indian J Physiol Pharmacol. 1987 Jan-Mar;31(1):30-4

(9) Takihara H, Cosentino MJ, Cockett AT. Zinc sulfate therapy for infertile male with or without varicocelectomy. Urology. 1987 Jun;29(6):638-41

(10) Madding CI, Jacob M, Ramsay VP, Sokol RZ. Serum and semen zinc levels in normozoospermic and oligozoospermic men. Ann Nutr Metab. 1986;30(4):213-8.

(11) Moslemi, M et al. Selenium – Vitamin E supplementation in infertile men: effects on semen parameters and pregnancy rate. Int J Gen Med 2011;4:99-104

(12) Moriyama H, et al. Studies on the usefulness of a long-term, high-dose treatment of methylcobalamin in patients with oligozoospermia. Hinyokika Kiyo. 1987 Jan;33(1):151-6.

(13) Sandler, B et al. The treatment of oligospermia with stilbestrol and vitamin B. Fertil Steril. 1961 Sep-Oct;12:469-73.

(16) C G Fraga, et al. Ascorbic acid protects against endogenous oxidative DNA damage in human sperm. Proc Natl Acad Sci U S A. 1991 December 15; 88(24): 11003–11006.

(14) Colagar AH, Marzony ET. Ascorbic Acid in human seminal plasma: determination and its relationship to sperm quality. J Clin Biochem Nutr. 2009 Sep;45(2):164-9.

(15) Dawson EB, Harris WA, Teter MC, Powell LC. Effect of ascorbic acid supplementation on the sperm quality of smokers. Fertil Steril. 1992 Nov;58(5):1034-9.

(16) Kessopoulou E et al. A double-blind randomized placebo cross-over controlled trial using the antioxidant vitamin E to treat reactive oxygen species associated male infertility. Fertil Steril. 1995 Oct;64(4):825-31.

(17) Geva E et al. The effect of antioxidant treatment on human spermatozoa and fertilization rate in an in vitro fertilization program.Fertil Steril. 1996 Sep;66(3):430-4.

(18) Aitken RJ et al. Analysis of the relationship between defective sperm function and the generation of reactive oxygen species in cases of oligozoospermia. J Androl. 1989 May-Jun;10(3):216-20.

(19) Lenzi, A., F. Culasso, L. Gandini, F. Lombardo, and F. Dondero. “Placebo-controlled, Double-blind, Cross-over Trial of Glutathione Therapy in Male Infertility.” Hum. Reprod. 8.10 (1993): 1657-62. Print.

(20) Shamsi, M.B., S. Venkatesh, M. Tanwar, P. Talwar, R.K. Sharma, A. Dhawan, R. Kumar, N.P. Gupta, N. Malhotra, and N. Singh. “DNA Integrity and Semen Quality in Men with Low Seminal Antioxidant Levels.” Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 665.1-2 (2009): 29-36. Print.

(21) Lenzi, A., F. Lombardo, L. Gandini, F. Culasso, and F. Dondero. “Glutathione Therapy for Male Infertility.” Arch Androl 29.1 (1992): 65-8. Print.

(22) Lenzi A et al. Glutathione therapy for male infertility. Arch Androl. 1992 Jul-Aug;29(1):65-8.

(23) Lewin A, Lavon H. The effect of coenzyme Q10 on sperm motility and function. Mol Aspects Med 1997; 18: S213-19 (5) Scibona M et al. L-Arginine and male infertility. Minerva Urol Nefrol. 1994 Dec;46(4):251-3.

(24) Lewin A, Lavon H. The effect of coenzyme Q10 on sperm motility and function. Mol Aspects Med 1997; 18: S213-19 (25) Pilz S et al. Effect of vitamin D supplementation on testosterone levels in men. Horm Metab Res. 2011 Mar;43(3):223-5.

FertilCare™

FertilCare™ проходил клиническое исследование на базе ЛНМУ имени Данила Галицкого (г. Львов). Факультет последипломного образования Кафедра акушерства, гинекологии и перинатологии, под наблюдением проф. Пироговой В.И. (СКАЧАТЬ ТЕКСТ ИССЛЕДОВАНИЯ)

Исследования, которые могут вас заинтересовать (номера ссылок в скобках):

Пре-концептуальная мультивитаминная добавка (1,18)

Магний: (2-3)
L-аргинин: (4)
Витамин C: (5-6)
L-таурин: (7)
Ниацин: (8)
Железо: (9)
Цинк / Медь: (10,12)
Витамин Е: (13)
Витамин B6: (14)
Рибофлавин: (15-17)
Фолиевая кислота: (10, 18-19)
Витамин D3: (20-25)
Витамин B12: (26 -28)

(1) Czeizel AE, Metneki J, Dudas I. The effect of pre-conceptional multivitamin supplementation on fertility. Int J Vitam Nutr Res 1996;66:55–8

(2) Howard JM, Davies S, Hunnisett A. Red cell magnesium and glutathione peroxidase in infertile women–effects of oral supplementation with magnesium and selenium. Magnes Res. 1994 Mar;7(1):49-57.

(3) J am Coll Nutr. 2004 Dec;23(6):694S-700S. New data on the importance of gestational Mg deficiency. Durlach J

(4) Battaglia, C. et al. Adjuvant L-arginine treatment for in-vitro fertilization in poor responder patients. Hum. Reprod. (1999) 16 (7): 1690-1697.

(5) M R Luck, I Jeyaseelan, R A Scholes. Ascorbic acid and fertility. Biology of Reproduction February 1, 1995 vol. 52 no. 2 262-266

(6) J. Millar. Vitamin c – the primate fertility factor? Medical Hypotheses, Volume 38, Issue 4, August 1992, Pages 292-295

(7) Aerts L, Van Assche FA. Taurine and taurine-deficiency in the perinatal period. J Perinat Med. 2002;30(4):281-6.

(8) Brent BE, Bartley EE. Thiamin and niacin in the rumen. Journal of Animal Science [1984, 59(3):813-822]

(9) Chavarro, Jorge E. MD, ScD1,2; Rich-Edwards, Janet W. MPH, ScD2,3,4; Rosner, Bernard A. PhD4,5; Willett, Walter C. MD, DrPH1,2,4. Iron Intake and Risk of Ovulatory Infertility. Obstetrics & Gynecology: November 2006 – Volume 108 – Issue 5 – pp 1165-1152

(10) Stang, J. PhD et al. Effects of Iron and Folic Acid Supplements on Serum Zinc Levels Among a Cohort of Pregnant Women. Clinical Nutrition September 2002 – Volume 17 – Issue 4 – p 15-26

(12) SOLTAN, M. H. and JENKINS, D. M. (1983), Plasma copper and zinc concentrations and infertility. BJOG: An International Journal of Obstetrics & Gynaecology, 90: 457–459

(13) Kaempf-Rotzoll, Daisy E.a,b; Traber, Maret G.c; Arai, Hiroyukia. Vitamin E and transfer proteins. Current Opinion in Lipidology: June 2003 – Volume 16 – Issue 3 – pp 249-254

(14) Durrane T. Pyridoxine (vitamin B6) supplementation in pregnancy. Cochrane database of systematic reviews 2006, Issue 2. Art. No.:CD000179.

(15) Sigfried Heller, Richard M. Salkeld, and Wilhelm F. Körner. Riboflavin status in pregnancy. Am J Clin Nutr November 1974 vol. 27 no. 11 1225-1230.

(16) Jessica Chan, Liyuan Deng, Leonie G Mikael, Jian Yan, Laura Pickell, Qing Wu, Marie A Caudill, and Rima Rozen. Low dietary choline and low dietary riboflavin during pregnancy influence reproductive outcomes and heart development in mice. Am J Clin Nutr April 2010 vol. 91 no. 4 1035-1043

(17) Powers HJ, Bates CJ. Effects of pregnancy and riboflavin deficiency on some aspects of iron metabolism in rats. Int J Vitam Nutr Res. 1984;54(2-3):179-83.

(18) E. Czeizel, I. Dudás, J. Métneki. Pregnancy outcomes in a randomised controlled trial of periconceptional multivitamin supplementation. Archives of Gynecology and Obstetrics July 1994, Volume 255, Issue 3.

(19) Scholl. T, Johnson. W. Folic acid: influence on the outcome of pregnancy1,2,3,4. Am J Clin Nutr May 2000 vol. 71 no. 5 1295s-1303s.

(20) Christopher S Kovacs. Vitamin D in pregnancy and lactation: maternal, fetal, and neonatal outcomes from human and animal studies1,2,3,4. Am J Clin Nutr August 2008 vol. 88 no. 2 520S-528S

(21) G. G. Kwiecinksi, G. I. Petrie, and H. F. DeLuca. 1,25-Dihydroxyvitamin D3 restores fertility of vitamin D-deficient female rats. AJP – Endo April 1, 1989 vol. 256 no. 4 E483-E487.

(22) N.Q. Liu, M. Hewison. Vitamin D, the placenta and pregnancy. Archives of Biochemistry and Biophysics Volume 523, Issue 1, 1 July 2012, Pages 37–47.

(23) Lewis. S, et al. Vitamin D deficiency and pregnancy: From preconception to birth. Molecular Nutrition & Food Research Volume 54, Issue 8, pages 1092–1102, August 2010.

(24) Marya R.K, Lal H, Chugh K, Saini A.S. Effect of Vitamin D Administration during Pregnancy on Neonatal Growth in the Rat. Ann Nutr Metab 1989;33:261–265.

(25) Laura E. Johnson and Hector F. DeLuca2. Reproductive Defects Are Corrected in Vitamin D–Deficient Female Rats Fed a High Calcium, Phosphorus and Lactose Diet. j. Nutr. August 1, 2002 vol. 132 no. 8 2270-2273.

(26) B-vitamin and homocysteine status determines ovarian response to gonadotropin treatment in sheep. Kanakkaparambil R, Singh R, Li D, Webb R, Sinclair KD. Biol Reprod. 2009 Apr;80(4):743-52.

(27) Bennett M. Vitamin B12 deficiency, infertility and recurrent fetal loss. J Reprod Med. 2001 Mar;46(3):209-12.

(28) Weiss, Rachel MD*; Fogelman, Yacov MD†; Bennett, Michael MBBS, FRCP, FRCPath. Severe Vitamin B12 Deficiency in an Infant Associated With a Maternal Deficiency and a Strict Vegetarian Diet. Journal of Pediatric Hematology/Oncology: April 2004 – Volume 26 – Issue 4 – pp 270-271.

FertilOva Plus™

Исследования, которые могут вас заинтересовать (номера ссылок в скобках):

Мио-инозитол, d-хиро-инозитол (1)

Vittorio Unfer, Fabio Facchinetti at all. Myo-inositol effects in women with PCOS: a meta-analysis of randomized controlled trials/ Endocr Connect. 2017 Nov; 6(8): 647–658.

Исследования

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